RANKL

RANKL
RANKL
	PDB прорисовано на основе 1s55.
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
	Список идентификаторов PDB 3URF
Идентификаторы
Символ	TNFSF11 ; CD254; ODF; OPGL; OPTB2; RANKL; TRANCE; hRANKL2; sOdf
Внешние ID	OMIM: 602642 MGI: 1100089 HomoloGene: 2744 GeneCards: Ген TNFSF11
Функция	• cytokine activity; • tumor necrosis factor receptor binding; • tumor necrosis factor receptor superfamily binding;
Компонент клетки	• extracellular region; • extracellular space; • cytoplasm; • integral component of plasma membrane;
Биологический процесс	• ossification; • osteoclast proliferation; • monocyte chemotaxis; • immune response; • activation of JUN kinase activity; • organ morphogenesis; • cytokine-mediated signaling pathway; • osteoclast differentiation; • tumor necrosis factor-mediated signaling pathway; • mammary gland epithelial cell proliferation; • positive regulation of homotypic cell-cell adhesion; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of MAP kinase activity; • bone resorption; • positive regulation of osteoclast differentiation; • positive regulation of bone resorption; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of JNK cascade; • positive regulation of T cell activation; • positive regulation of sequence-specific DNA binding transcription factor activity; • positive regulation of NF-kappaB transcription factor activity; • protein homooligomerization; • positive regulation of corticotropin-releasing hormone secretion; • positive regulation of protein kinase B signaling; • calcium ion homeostasis; • mammary gland alveolus development; • ERK1 and ERK2 cascade; • positive regulation of fever generation by positive regulation of prostaglandin secretion; • TNFSF11-mediated signaling pathway; • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling; • positive regulation of intracellular signal transduction;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
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Ортологи

TNFSF11, или RANKL (от англ. Tumor necrosis factor ligand superfamily member 11; Receptor activator of nuclear factor kappa-B ligand) — мембранный белок, цитокин семейства факторов некроза опухоли. Продукт гена человека TNFSF11. Играет важную роль в метаболизме костной ткани, активируя остеокласты.